I Suggest - Cancer

According to World Bank statistics, in 2001 year were registered about seven million deaths worldwide from

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

cancer. This is a high amount of men and women. But the big concern is that 35 percent from deaths were a

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

tributable to the only nine behavioral and environmental risk factors, with alcohol and smoking playing la

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ge roles. That means more than one in every three of the seven million deaths from cancer worldwide was ca

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

sed by nine risk factors that people can easily eliminate from their habits.

The above nine modifiable ri

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

k factors were:

Smoking.
Smoking alone is estimated to have caused 21 percent of deaths fr

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

m cancer worldwide.

Alcohol use.
Mouth cancer caused by alcohol use killed more people in the UK

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

than cervical cancer and testicular cancer put together. When tobacco and alcohol use are combined, the r

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

sk of oral cancer increases 15 times. Alcohol is also a primary cause of liver cancer.

Overweight an

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

obesity.
One in 10 cancers affecting non-smokers is caused by the sufferer being overweight.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

fruit and vegetable intake.
It has been estimated that about 25,000 different chemical compounds occ

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

r in vegetables and fruits. Studies show that more than 500 of these compounds are potential modifiers of

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

he cancer process.

Physical inactivity.
Physical inactivity is strongly linked to colorectal can

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

er, as well as to a important number of dietary risk factors.

Unsafe sex.
Sexual transmission of

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

human papilloma virus is the leading risk factor for cervical cancer in women.

Urban air pollution.<

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

r> In France, urban air pollution, most of it caused by cars, buses and trucks, kills more than 5,000 peo

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

le every year.

Indoor smoke from household use of coal.
It is stated that a pollutant released i

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

doors is many times more likely to reach the lung than that released outdoors.

Contaminated injection

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

in healthcare settings, like unsafe blood transfusions.

These conclusions clearly show that very

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

mportant types of cancer are preventable by changes in lifestyle behaviors and environmental interventions

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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I Suggest - Cancer-35 Percent of Deaths Caused by 9 Modifiable Risk Factors

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