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Holidays come pre-packaged with stress – thanks to relatives, airports, malls and bills. The usual demands of the holiday season can stretch yo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ur physical and emotional limits, and if you are not prepared, leave you so stressed you are unable to enjoy special times. With all the shopping, cooking, planning,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

spending, and traveling, it is so easy to fall into the trap of doing too much, ignoring our own needs, and ending up in meltdown mode. A sense of control lessen

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the stress load. Cultivate the conscious intention to care of yourself and those holiday obligations in a more centered way. Here are five simple ways to t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

me holiday stress and nurture your own spirit:

1. Start Early. Give yourself plenty of time to get prepared. The earlier you get things done, the more time

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

you’ll have to enjoy parties and other holiday activities. When preparing for holiday events and activities, allow plenty of time to avoid unneeded stress and last-m

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nute rushing.

2. Avoid Caffeine. Coffee, tea, cola, ‘energy’ drinks and chocolate are used so unconsciously in our culture that most users have no idea the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

y are mind-altering drugs. These caffeine containing foods and drinks can make you feel jumpy, anxious, and fearful. They can interfere with your ability to relax an

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

sleep, thus compounding holiday stress. Try herbal teas blended for relaxation.

3. Lighten Up. Some people are especially sensitive to lack of sunlight. Si

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ce daylight is scarce in winter months, holiday blues can be amplified. Exposure to full-spectrum lights may brighten your spirits. Try to get outside for a while ea

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

h day, preferably for some exercise or a meditative walk. 20 minutes outside right now will make you feel better.

4. Exercise. A brisk walk, a group fitness c

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ass, or thirty minutes of strength training can naturally relieve holiday-induced tension. Exercise also helps neutralize the damage Christmas cookies and eggnog r

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ek on waistlines. Acknowledge that you probably will not always have time for your full workout routine during the holidays, and plan for that. Do what you can, but

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

on’t stop.

5. Breathe. Conscious breathing is the single most effective relaxation technique. When you feel like a Christmas cookie about to crumble, try th

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

is simple yogic breathing exercise…it’s simple and can be done anywhere:

-Place the tip of your tongue against the ridge of tissue just behind your upper front teeth

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

Keep it there during the exercise as comfortable.

-Exhale completely through your mouth, making a ‘whoosh’ sound.

-Next, close your mouth and inhale quietly through

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

your nose to a mental count of four.

-Hold your breath for a count of seven.

-Then, completely exhale through your mouth, making a ‘whoosh’ sound to a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

count of eight.

This is one breath cycle. Now, inhale again and repeat the cycle three more times for a total of four breaths.

Knowing the

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

difference between changeable and unchangeable sources of stress does require wisdom. A positive attitude is an invaluable tool. An optimistic focus is essential for

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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