I Suggest - Home Improvement

Yorkstone is one of those quintessential English stones that everyone has heard about but how many people actually know what a very special stone Yorkstone really is? Of all

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the natural stones quarried in the UK York stone is probably the most versatile. Used for paving, house signs, headstones, fireplaces and all types of buildings from church

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

es to office blocks. Yorkstone is now increasingly the stone of choice for house signs.

Yorkstone is a sedimentary Limestone, that is a stone laid down from the sediment of

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ong disappeared lakes and seas. This process means that all sedimentary limestone’s are to a greater or lesser degree layered or stratified. The strata on stones such as Port

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

land or Bath stone are deep and each layer or strata can produce a different class of stone some with fine clear stone, some with heavy fossilised shell. However, York stone

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s laid down in fine layers of just a few millimetres thick per layer.

It is this layering that gives Yorkstone much of its character. The stone is constructed in layers or s

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

trata, that can be seen in the edge of the stone. This forms a dense hard stone with greater tensile strength than most other limestone’s.

It is this tensile strength and ha

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rdness that makes York stone so suitable as paving. Yorkstone paving slabs have an incredible capacity for wear and tear, and today old York paving originally laid down a hu

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

dred or more years ago is a prized and expensive re-claimed commodity.

The colour of new Yorkstone tends to be mainly buff or gold, but old Yorkstone was commonly available

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

in greys and dark browns as well as a true blue! This variety of colour and hue made Yorkstone the material of choice for fireplace builders in the eighties. As a young man

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

built hundreds of these fireplaces, sadly out of fashion now of course.

Yorkstone is ideal for engraving as it seldom shows sign of the fossil shell that can mar the finish

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

of other limestone’s and the colour generally remains fairly uniform throughout the slab or block though can darken when a new layer or strata is cut through. The density of

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

the grain means that engravings and carvings are crisp and sharp.

This uniformity and consistency is one of the reasons Yorkstone has always been valued for its suitability

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

for engraving. It has been used for generations for headstones and today is being increasingly chosen for engraved house signs and commemorative plaques.

Yorkstone has other

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

attributes less well known, for instance did you know that it is an excellent fine abrasive? All stone masons yard and workshops used to have a block of Yorkstone and a larg

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

hand turned Yorkstone wheel for sharpening chisels. Lubricated with water the stone was often the only sharpening stone available. Another use was to finish off the leaded l

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ettering on headstones. After the lead had been hammered into the finished letters, they were rubbed over with a piece of York stone and water, this flattened and blackened t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

he lead at the same time.

Lastly the reason I love this stone is its ability to age and weather gracefully. Old York stone headstones, walls and signs hundreds of years ol

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

, covered in moss, and the grime of history with the inscriptions all but unreadable are still very beautiful and the quality of the stone still shines through!

One word

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

of warning, the dust created by dry cutting Yorkstone can be a serious health risk, if you are going to work Yorkstone wear a proper respirator or better still cut it wet.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

Tags

Links

I Suggest - Yorkstone, The Ideal Stone for Engraved House Signs and Commemorative Plaques

Related Articles: